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Individual differences can best be characterized by the age at which symptoms appear. It is not so much a matter of whether you develop dementia - it will probably happen to us all if we live long enough - but how old you are at the time.J 2! 2xWPHow much time elapses between first signs or symptoms of dementia and diagnosis?QQ$  :How quickly do seizures develop following diagnosis of AD?;;Of our 88 adults with Down syndrome who were demented: 5 had a history of seizures from before the age of 40; 44 (52%) developed seizures following onset of dementia; 39 (44%) have, as yet, no history of seizures. .77![How long will it be before a move will have to be made to a more service intensive program?\\(Of the 88 adults with Down syndrome and dementia, 8 were already in nursing homes the first time we saw them: 20 individuals moved to a more service intensive program following the onset of dementia. .n[n[" How does Alzheimer s Disease Affect Survival of Adults with Down Syndrome?@K0$($45 adults with Down syndrome and dementia have died since the beginning of our study. Does dementia have an impact on mortality risk? Is the impact of dementia on mortality risk greater than what we see in the general population?# Conclusions $Alzheimer s disease has devastating consequences for any affected individual. For adults with Down syndrome, rate of progression seems slightly increased, but, nevertheless: Mortality risk is low during the first two years following diagnosis. Rate of progression varies substantially among individuals. Anecdotal reports of adults with Down syndrome  falling off a cliff reflect unusual cases. In such cases, severe symptoms may be due to some additional, perhaps treatable problem. In all cases, careful vigilance and thoughtful support can contribute positively to quality of life.Z0Z2Y0Z2e0Z2fYeSources of SupportNew York State through its Office of Mental Retardation and Developmental Disabilities NICHD Grants: PO1 HD22634, PO1 HD35897, RO1HD37425 NIA Grants: PO1 AG11537, RO1 AG14771, RO1AG14673Z&"Essential Partnerships&9Cooperating Agencies (100+) Volunteer Participants (500+)::TIBR s Aging Research Program Investigators$+*$fPsychology: W. Silverman, D. Devenny, W. Zigman, S. Krinsky-McHale, T. Urv, H. Kim, P. Kittler, C. Miezejeski Epidemiology: N. Schupf Immunology: P. Mehta Genetics: E. Jenkins, W.T. Brown, S. Sklower-Brooks, N. Zhong Neuropathology: J. Wegiel, T. Wisniewski, (H. Wisniewski,) Neurology: K. Wisniewski, R. Schubert Statistics: L. Muenz, M. FloryoZZ.ZZ@ZZ=Z)Z!Z@f ~IBR s Aging Research Program Collaborators: Columbia University$@?$jR. Mayeux, B. Tycko, D. Warburton Yaakov Stern, Jennie Kline, Michel Ferin, Susan Winsten, Anna Greenacre R"H Z ZiDIBR s Aging Research Program Staff$#"$Coordinators: C. Marino, D. Pang, R. Ryan, C. Stolzenthaler, D. Swift Current Research Support Staff: T. Bach, D. Conlon, L. Kullman, L. McLendon, G. Palma, B. Patel, A. Trzeciak, M.S. Vietze, J. Wegiel, L.L. Ye. d9$8$!%! ` ̙33` ` ff3333f` 333MMM` f` f` 3>?" dd@,|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> $(    6 P  T Click to edit Master title style! !  0   RClick to edit Master text styles Second level Third level Fourth level Fifth level!     S  0 ``  X*  0 `   Z*  0 `   Z*H  0޽h ? 33̙33 $Blank Presentation@ (    0. P   . X*   0|.    . Z*   6P. `P  . X*   6. `  . Z* H  0޽h ? ̙33 000(  0x 0 c $x+  + x 0 c $4+ `   + H 0 0޽h ? ̙33  P0(  Px P c $x.@  . x P c $ . . H P 0޽h ? 3f33  40(  4x 4 c $.P  . x 4 c $H.`  . H 4 0޽h ? 33f33  DB(  Dx D c $P    D c $.    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Ya;ELRAgikc8GNT]\5me  n&tOh+'0H hp  ( 4 @LTNo Slide TitleWarren ZigmanCC:\Program Files\Microsoft Office\Templates\Blank Presentation.potmariagr21iMicrosoft PowerPointoso@49@:rB@YI &eGg  ?& &&#TNPP$2OMi & TNPP &&TNPP    33--- !---&G&j}w@ UQwZw0- &Gy& --1yXH-- @Times New RomanQwZw0- .:2 "Individual Differences in Rate of    $     . .?2 U%Progression of Symptoms Among Adults    %% "& "  . .62 with Down Syndrome and Dementia#  $$ %  #% .--Q1-- @Times New RomanQwZw0- .72  Wayne Silverman, Warren Zigman, )  ! )    . .72  Nicole Schupf, Darlynne Devenny        . .2 ,Pand Robert Ryant  .--"System 0-&TNPP &t՜.+,00     On-screen Show NYSIBRDD Shn Times New RomanBlank PresentationgIndividual Differences in Rate of Progression of Symptoms Among Adults with Down Syndrome and DementiamReceiving a diagnosis of dementia raises important concerns for anyone, including adults with Down syndrome./Progression of Symptoms in Alzheimers Disease!Determining Rate of Progression 'Adults with Down Syndrome and Dementia^Interpreting Symptoms in Adults with Down Syndrome: Two Overriding Conceptual ConsiderationsQHow much time elapses between first signs or symptoms of dementia and diagnosis?PowerPoint Presentation;How quickly do seizures develop following diagnosis of AD?PowerPoint Presentation\How long will it be before a move will have to be made to a more service intensive program?PowerPoint PresentationKHow does Alzheimers Disease Affect Survival of Adults with Down Syndrome?PowerPoint PresentationPowerPoint Presentation ConclusionsSources of SupportEssential Partnerships+IBRs Aging Research Program Investigators@IBRs Aging Research Program Collaborators: Columbia University#IBRs Aging Research Program StaffPowerPoint Presentation  Fonts UsedDesign Template Slide Titles_Lomariamaria  !"#$%&'()*+,-./012345789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmopqrstuwxyz{|}Root EntrydO)PicturesskCurrent User~SummaryInformation(nPowerPoint Document(6poDocumentSummaryInformation8v